Determining the optimal strategy for the live-attenuated herpes zoster vaccine in adults
نویسندگان
چکیده
منابع مشابه
Immunogenicity and Safety of the HZ/su Adjuvanted Herpes Zoster Subunit Vaccine in Adults Previously Vaccinated With a Live Attenuated Herpes Zoster Vaccine
Background Protection against herpes zoster (HZ) induced by the live attenuated zoster vaccine Zostavax (ZVL) wanes within 3-7 years. Revaccination may renew protection. We assessed whether (re)vaccination with the adjuvanted HZ subunit vaccine candidate (HZ/su) induced comparable immune responses in previous ZVL recipients and ZVL-naive individuals (HZ-NonVac). Methods In an open-label, mult...
متن کاملHerpes zoster vaccine in older adults and the risk of subsequent herpes zoster disease.
CONTEXT Approximately 1 million episodes of herpes zoster occur annually in the United States. Although prelicensure data provided evidence that herpes zoster vaccine works in a select study population under idealized circumstances, the vaccine needs to be evaluated in field conditions. OBJECTIVE To evaluate risk of herpes zoster after receipt of herpes zoster vaccine among individuals in gen...
متن کاملReal-World Effectiveness and Safety of a Live-Attenuated Herpes Zoster Vaccine: A Comprehensive Review
UNLABELLED Herpes zoster (HZ) is a common, painful and debilitating disease caused by the reactivation of latent varicella-zoster virus in ganglia. This clinical event occurs more frequently in the elderly and those who are immunocompromised. The most common complication of HZ is post-herpetic neuralgia (PHN) which is responsible for the highest HZ-related burden of illness and is challenging t...
متن کاملBoosting Immunity in Recipients of Live-Attenuated Zoster Vaccine.
Roughly a million cases of herpes zoster (HZ) occur annually in US adults, and nearly one third of these patients will experience postherpetic neuralgia (PHN) lasting for ≥1 month [1]. The burden of HZ is strongly influenced by age: the incidence of HZ increases many fold throughout adulthood, and among adults who experience HZ, the risk that PHN will develop increases several fold more after t...
متن کاملClinical Usage of the Adjuvanted Herpes Zoster Subunit Vaccine (HZ/su): Revaccination of Recipients of Live Attenuated Zoster Vaccine and Coadministration With a Seasonal Influenza Vaccine.
Michael N. Oxman,1,2 Ruth Harbecke,1,3 and David M. Koelle4,5,6 1Department of Medicine, Division of Infectious Diseases, University of California, San Diego, La Jolla; 2Medicine Service, Infectious Diseases Section and 3Research Service, Veterans Affairs San Diego Healthcare System, California; and 4Departments of Medicine, Laboratory Medicine, and Global Health, University of Washington, 5Vac...
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ژورنال
عنوان ژورنال: Vaccine
سال: 2018
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2018.06.059